Organokines in COVID-19: A Systematic Review.

Coronavirus disease 2019 (COVID-19) is a viral infection caused by SARS-CoV-2 that induces a generalized inflammatory state. Organokines (adipokines, osteokines, myokines, hepatokines, and cardiokines) can produce beneficial or harmful effects in this condition. This study aimed to systematically review the role of organokines on COVID-19. PubMed, Embase, Google Scholar, and Cochrane databases were searched, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed, and 37 studies were selected, comprising more than 2700 individuals infected with the virus. Among COVID-19 patients, organokines have been associated with endothelial dysfunction and multiple organ failure due to augmented cytokines and increased SARS-CoV-2 viremia. Changes in the pattern of organokines secretion can directly or indirectly contribute to aggravating the infection, promoting immune response alterations, and predicting the disease progression. These molecules have the potential to be used as adjuvant biomarkers to predict the severity of the illness and severe outcomes.

Risk Factors and Individual Protection Measures for COVID-19 in Federal Police Officers

The coronavirus of severe acute respiratory syndrome 2 (SARS-CoV-2), known as COVID-19, has spread rapidly around the world, leading to social detachment and the home office replacing face-to-face work. The performance of police officers faces limitations to the new requirements while recognizing the need to ensure health and quality of life. Thus, the present study aimed to verify the panorama of the spread of COVID-19 among federal police officers by analyzing the presence of symptoms, individual protection measures (IPM), and suspect screening measures (SSM). For this, data were collected through a questionnaire customized for this situation and measurements of clinical data from 56 federal police officers in the municipality of Marília (São Paulo, Brazil) were performed. The mean value of the body mass index (27.2 ±5.4 kg/m2) suggests overweight and obesity, in addition to the presence of hypertension at 16.1%, diabetes at 3.6%, asthma at 3.6%, and obesity at 25%, which represents an important risk of complications for COVID-19. The use of a mask is the most frequent IPM (96.4%) and most of the sample has used a cloth or home mask (90.9%). However, 47.3% have not performed the correct cleaning of the masks and 5.5% have not taken any care with mask hygiene. In conclusion, although the IPM was adopted by most of the research participants, some did not adopt important measures such as wearing a mask, which can increase the risk of contamination and contagion due to the work environment and routine. The highest risk factors observed were obesity and hypertension, but even in these conditions, the absence of important IPMs was still verified.